The Consultant Pharmacist is published by the
American Society of Consultant Pharmacists.

Health Trends

Supportive Housing: A Market in Motion

A report released earlier this year by the Public Policy Institute of the American Association of Retired Persons confirms that assisted living is the fastest growing housing segment for seniors in the United States.

The report, New Directions for State Long-Term Care Systems Volume III: Supportive Housing, provides definitions of several types of supportive housing options and outlines some of the issues states face in regulating this growing market.

The report distinguishes among several types of supportive housing:

Information Central

Four drug information centers have joined forces to create an academically based drug and health information network for health care professionals and consumers.

The Drug Information Network consists of the Chesapeake, Virginia-based Center for Health Information, the Medical University of South Carolina, North Carolina Baptist Hospital, and the University of Maryland School of Pharmacy. The four centers currently answer more than 10,000 drug and health information requests annually.

The target customer base of the new network includes hospitals, managed care organizations, long-term care pharmacy providers, physician practice management companies, pharmacy benefit organizations, demand management companies, contract research organizations, and pharmaceutical companies.

The Drug Information Network hopes to become "the premier drug information training program for students and residents," according to CHI Chief Operating Officer Steven F. Bauwens. The network has established three drug information residency programs to provide training for students and residents in both an academic medical center and a practice-based pharmaceutical care management company.

For more information, contact Bauwens at 757-483-6117, or visit the Center for Health Information web site at www.ctr4healthinfo.com.

Early Warning

A sudden rise in blood pressure upon awakening is linked to a potentially dangerous enlargement of the heart's main pumping chamber, according to information published in the May 1997 issue of the American Journal of Hypertension.

Results of a ten-year study of 181 patients showed a strong statistical relationship between early morning blood pressure readings and the size of the left ventricle, the part of the heart that pumps blood to most of the critical parts of the body. Enlargement of the left ventricle is often associated with serious cardiovascular events such as heart attack, stroke, or death.

Researchers at the Hospital Saint Andre in Bordeaux, France, followed 128 men and 53 women with hypertension who were previously untreated from 1986 to 1996. Blood pressure was measured three times in a physician's office, and then echocardiography was performed to measure the weight and wall thickness of the left ventricle.

Patients were fitted with ambulatory blood pressure monitoring devices to automatically record blood pressure throughout the day and were instructed to trigger their device immediately upon awakening and standing.

Though almost all people experience a rise in blood pressure and heart rate when they wake up, researchers reported that the blood pressure of patients with enlarged left ventricles was strikingly higher, by an average 19 mm Hg systolic and 16 mm Hg diastolic.

"We found a highly significant correlation between blood pressure measured immediately after arising in the morning and left ventricular mass in untreated hypertensive patients," the researchers said.

Nearly 50 million Americans have high blood pressure, sometimes called the silent killer because it prematurely ages the body's arteries and can lead to strokes, heart attacks, and kidney failure, often without warning.

Overcoming Barriers to Mental Health

According to some estimates, 80%-90% of the nation's nursing home residents suffer from mental health problems, including depression, anxiety, schizophrenia, dementia, delirium, and behavioral symptoms.

A recent report, titled "Achieving Mental Health of Nursing Home Residents: Overcoming Barriers to Mental Health Care," reviews policy, relevant research, and current recommendations based on a national consensus conference of the same name addressing the mental health of nursing home residents.

The 56-page report examines prevalence, current treatment options, examples of model programs, reimbursement and policy issues, funding, and quality management.

For more information, contact the Hebrew Rehabilitation Center for the Aged, one of the support sponsors, at 617-325-8000.

Easy Does It When Stopping Antidepressants

Data presented this spring at the World Psychiatric Association Congress in Geneva indicate that abrupt discontinuation or interruption of antidepressant treatment can produce symptoms such as dizziness, nausea and vomiting, anxiety and agitation, and sleep disturbances. These symptoms may occur as a result of planned discontinuation, or as a result of patient noncompliance.

Though discontinuation symptoms are usually mild and transient, they pose the risk of misdiagnosis and may lead to inappropriate treatment, said symposium chairman Chris Thompson.

Reports regarding the discontinuation of SSRIs suggested that adverse events occurred most frequently with paroxetine, and rarely with fluoxetine.

Jerrold Rosenbaum, MD, of Boston, Massachusetts, described a study in which intermittent patient non-compliance was mimicked by interrupting treatment with a placebo phase in a double blind study of continuing antidepressant therapy with fluoxetine, paroxetine, and sertraline.

Fluoxetine was found to cause significantly fewer discontinuation symptoms than either of the other two antidepressants.

Symposium participants recommended that pharmacists support patients in the following ways:

Nonprofit Nursing Homes on the Rise

Though most nursing homes are still operated for profit, the number of for-profit homes decreased by 23.1% between 1985 and 1995, while the number of nonprofits increased by 13.2%, according to data presented in the U.S. Department of Health and Human Services' 1995 National Nursing Home Survey. In addition, more than half were operated as part of a chain in 1995, compared with 41.4% in 1985 and 28% in 1977 (see chart).

Number of Nursing Homes by Ownership, Affiliation, and Certification Status: United States, 1995
________________Certification______________
Ownership and AffiliationTotal Certified by Medicare and Medicaid Certified by Medicare Only Certified by Medicaid OnlyNot Certified
All Facilities 16,700 11,600*1,0003,400 *700
Ownership
Proprietary 11,000 8,100 * 2,200 300
Voluntary nonprofit 4,300 2,700 * *800 300
Government and other 1,300 800 * * *
Affiliation
Chain 9,100 7,100 *600 1,200 *
Independent 7,600 4,500 * 2,100 *600
* Figure does not meet standard of reliability or precision (sample size less than 30) and is therefore not reported. If shown with a number, it should not be assumed reliable because the sample size is between 30-59 or the sample is greater than 60 but has a relative standard error over 30 percent.
Note: Numbers may not add to totals because of rounding.
Source: Centers for Disease Control and Prevention/National Center for Health Statistics/1995 National Nursing Home Survey.


PPMs Develop Clinical Trial Programs

Some physician practice management companies (PPMs) are beginning to develop clinical trial programs in an effort to provide pharmaceutical companies with access to large numbers of physicians, patients, and cost-outcomes data, according to CenterWatch, a trade publication focusing on the clinical trials industry.

CenterWatch reports that the PPMs' deep resources, including private research centers, physicians, patients, capital, and information systems, will make them important competitors for academic medical centers, private research centers, and contract research organizations.

PPMs that are becoming involved in clinical trials say their physicians want the chance to participate in clinical trials, they want to provide their patients with promising investigational drugs, and they believe that participating in clinical trials will complement their own outcomes research.

Providers, Consumers Voice Frustrations Over Managed Care

As managed-care organizations have extended their reach to cover more than three-quarters of the nation's private sector employees, health care consumers and their physicians are becoming increasingly vocal about their concern that MCOs are endangering patients' health through over-zealous cost-cutting measures. In response, state lawmakers across the country are rushing to push through legislation designed to curb the power of managed health-care plans.

In June, the governor of Missouri signed into law a statute requiring managed-care companies to pay for emergency-room visits whenever a "prudent layperson" would judge that immediate care is needed, regardless of whether a managed-care administrator would agree.

In Texas, a law enacted this summer allows consumers to sue managed-care plans for malpractice. In New York, an unusual coalition of doctors, lawyers, hospitals, consumers, and labor groups is backing a bill allowing consumers to sue health insurance companies for medical malpractice if a decision to deny or delay treatment causes injury. And in Connecticut, lawmakers approved a bill allowing consumers to appeal to the state insurance commissioner if their managed-care plan refuses to pay for medical treatment.

The movement is being fueled by "horror stories" such as that of Leon Hand, a Texas resident whose experience was reported in the May 31 issue of USA Today. Hand arrived at the emergency room of a hospital run by a managed-care company complaining of a headache which had persisted for three days. Hand was sent home, despite a history of high blood pressure, a family history of aneurysms, and a recommendation that he be hospitalized. Three hours later, Hand suffered a stroke.

Many managed-care executives remain upbeat in the face of this growing unrest, citing unrealistic consumer expectations and pointing to polls reflecting high rates of consumer satisfaction with their managed-care plans. A recent survey conducted by Sachs/Scarborough/ Health Plus showed that more than 80% of consumers in eight major U.S. cities are happy with their health maintenance organizations.

Why the discrepancy? According to a group of activist physicians in Boston who have drafted a petition calling for an end to for-profit takeovers of medical facilities and an open discussion of the deteriorating quality of medical care, the reasons are clear: "For the public, who are mostly healthy and use little care, awareness of the degradation of medicine builds slowly; it is mainly those who are expensively ill who encounter the dark side of market-driven health care," says their statement.

Some statistics appear to back them up. Sachs Scarborough survey participants in Florida, where many elderly people live, were among those least satisfied with their HMOs.

No Place for Creative License

A medication order is not the place to fine-tune your artistic or creative writing skills. This was the strong recommendation of a team from Promina Gwinnett Health System in Lawrenceville, Georgia, after it sought to reduce medication errors by standardizing symbols and abbreviations used on medication orders.

When the team conducted a random analysis of one thousand medication order sheets during a six-week period, they discovered that approximately half of the sheets contained a source for possible error, such as illegible handwriting or incomplete dosage instructions. It also found a remarkably high incidence of unapproved abbreviations, including "trademark" abbreviations and symbols that incorporated Latin or Greek.

Twenty-seven percent of the error-prone order sheets contained an unapproved symbol or some other "creative" notation. Instructions included such things as "IVP" for IV push, "Neb" for nebulizer, "H/A" for headache, "MSO4" for morphine sulfate, and an asterisk or degree mark to signify "hour."

Unfortunately, the hospital's attempt to rectify the problem was less than successful. "We isolated the top 20 'stylistic' practitioners," said Charles A. Krivenko, MD, vice president for system clinical services. "We sent them a letter. I called each one." A subsequent audit of 350 order sheets, however, revealed no significant improvement.

Krivenko has come to the conclusion that automation may provide the only real solution for overly individualistic prescription writers. In the meantime, Promina Gwinnett's tactic for dealing with its creative writers is one of direct confrontation: For example, if a physician writes 1 mg of Coumadin as 1.0 mg, the pharmacist will immediately let the physician know that the 1.0 could have been mistaken for a 10, and a patient might have died as a result.


Take a Deep Breath

A new device designed to monitor medication use from metered dose inhalers may provide a way for patients and caregivers to improve compliance and collect accurate and objective data on MDI use.

Newton, Massachusetts-based NEWMED Corporation's DOSER, which has received U.S. Food and Drug Administration 510K clearance, uses a self-contained microcomputer to count and display the number of inhalations taken in a current day and the number of inhalations remaining in the MDI. The device also stores information on the number of inhalations taken in each of the last 30 days and alerts the user when the MDI is nearly empty. With its self-contained battery, the DOSER lasts up to a year.

A three-part validation study presented at the American Lung Association-American Thoracic Society International Conference in May concluded that the DOSER is "reliable and accurate for measuring MDI usage." Data showed that accordance between the DOSER and tracking diaries ranged from 85%-98%, with the device performing well in both controlled laboratory situations and actual usage studies with asthma patients.

For additional information, visit the NEWMED web site at www.DOSER.com, or call 800-863-9633.


Point of Entry

The federal government has joined the vast array of health and medical information sources on the World Wide Web with Healthfinder (www.healthfinder.gov), a new site with links to hundreds of online documents and more than 550 health information sites maintained by federal, state, and local governments, universities, and other groups.

Healthfinder employs an easy-to-use format to link the user to medical news, new drug information, research studies, and frequently asked questions on a wide variety of health-related subjects.

Greenstone Health Care Solutions, the disease management subsidiary of Pharmacia & Upjohn, Inc., now offers consumers a free, confidential health risk assessment via the World Wide Web.

"You First" (www.youfirst.com) analyzes answers to questions about family history, health habits, and lifestyle behaviors, then creates a personalized report with tips for avoiding future problems and maximizing health.

Aging Information Resources from NCOA

Professional development tools, training manuals, research reports, reference books, videos-the National Council on Aging's Information Resources Catalogue offers a selection of information resources organized around four areas: aging and society, program enrichment for professionals, life enrichment for seniors, and religion and aging. For more information call 800-867-2755.


Dangerous Acronyms

Irinotecan (Camptosar) belongs to a class of anti-tumor agents called camptothecins. However, notes the June 18, 1997 issue of ISMP Medication Safety Alert!, it is sometimes dangerously referred to in protocols and literature reports by its acronym, "CPT" or "CPT-11."

Recently, when a pharmacist received an order for "CPT 200 mg in 500 mL over 90 minutes," he thought that cisplatin (Platinol) had been prescribed. Wisely, he consulted with another pharmacist, who remarked that a cisplatin dose that high could prove toxic for this patient.

The pharmacists also considered that CPT might represent carboplatin (Paraplatin), but the dose seemed low for that drug. They decided to check with the prescriber and learned that CPT was an acronym for irinotecan.

Given the dosage ranges for the above agents, as well as numerous reports of dosing errors on file at the United States Pharmacopoeia and at FDA, it's clear that confusion between these could lead to patient harm or death, notes ISMP. Their recommendation: Where irinotecan is available, take action now to ensure that all regimens and protocols properly refer to Campostar. For safety reasons, only generic and/or brand names should be acceptable for chemotherapy prescriptions. The acronym "CPT" is extremely dangerous and should never be used.

The Consultant Pharmacist is published by the
American Society of Consultant Pharmacists.