Take the "Pharmacotherapy" Assessment

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  1. Which of the following gastrointestinal medications can lower someone's seizure threshold, exacerbate Parkinson's symptoms, as well as potentially cause restlessness/insomnia or drowsiness?
    1. Bismuth subsalicylate
    2. Cimetidine
    3. Lansoprazole
    4. Metoclopramide
  2. Which of the following classes of medications has a box warning on the package insert regarding an increased risk of death in older adults with dementia who take the medication?
    1. HMG-CoA reductase inhibitors
    2. Atypical antipsychotics
    3. Conjugated estrogens
    4. Acetylcholinesterase inhibitors
  3. Which combination of medications exceeds the maximum daily dose of acetaminophen for a typical senior patient?
    1. Oxycodone/acetaminophen 5/325mg Q6H routinely and acetaminophen 325mg – 2 tabs Q6H PRN (averaging 4 tabs per day)
    2. Acetaminophen 325mg – 2 tabs Q6H routinely
    3. Acetaminophen 500mg Q6H routinely and hydrocodone/ acetaminophen 5/500mg Q4H PRN (averaging 4 tabs per day)
  4. For a 75-year old woman with severe anxiety disorder, which benzodiazepine would be a better treatment choice in order to minimize the risks of her falling?
    1. Alprazolam
    2. Diazepam
    3. Clorazepate
  5. Which of the following drug classes is most often associated with cognitive decline?
    1. Diuretics
    2. Benzodiazepines
    3. Antidepressants
    4. Antiarrhythmics
  6. A 72 year-old woman presents to the geriatrics clinic with recent onset of osteoarthritis of the left knee. She describes her pain as 3 on a 10-point scale. She denies any history of hypertension, heart failure, or gastrointestinal problems. Which of the following is the most appropriate treatment for this patient's osteoarthritis?
    1. Acetaminophen
    2. Naproxen sodium
    3. Tramadol/acetaminophen
    4. Hydrocodone/acetaminophen
  7. Which of the following changes is associated with the aging process?
    1. Reduction of Phase I hepatic metabolism
    2. Decreased percent of body fat
    3. Increased amount of total drug metabolism body water
    4. All of the above
  8. A 90 year-old community-dwelling patient has long-standing hypertension. His current regimen includes enalapril, hydrochlorothiazide, atenolol and clonidine. Blood pressure is minimally controlled. Goals for this patient should include:
    1. Reducing the number of antihypertensive medications
    2. Successfully controlling hypertension
    3. Preventing adverse medication events
    1. 1 and 2 only
    2. 1 and 3 only
    3. 2 and 3 only
    4. 1, 2, and 3
  9. A new resident of the dementia unit is wandering, increasingly confused, and bothering the staff with many questions. Which of the following is the most appropriate recommendation at this time?
    1. Risperidone 1 mg daily
    2. Quetiapine 25 mg bid PRN
    3. Redirection of the resident PRN
    4. A lap belt or a geri-chair
  10. A 75 year-old patient has been receiving levothyroxine 50 mcg daily for 2 months. Her TSH is reported at 9.2 mU/L (normal = 0.5 - 5.0 mU/L). Which of the following is the best recommendation?
    1. Increase daily dose to 75 mcg, and recheck TSH in two weeks.
    2. Increase daily dose to 75 mcg, and recheck TSH in two months.
    3. Decrease daily dose to 25 mcg, and recheck TSH in two weeks.
    4. Decrease daily dose to 25 mcg, and recheck TSH in two months.
  11. An 82 year-old female began showing symptoms of memory problems and was referred to a neurologist by her primary physician. The neurologist diagnosed Alzheimer's disease and initiated therapy with donepezil. Six weeks after therapy began, the patient made an appointment with her primary physician to ask for an "overactive bladder" medicine that she saw advertised on television. The primary physician initiated therapy with darifenacin. This patient is an example of:
    1. Use of a "Beers criteria" medication
    2. Geriatric syndrome
    3. Prescribing cascade
    4. Drug toxicity
  12. A study comparing the efficacy of two antibiotics reports a p value of 0.04. Which of the following is the most commonly accepted conclusion?
    1. Neither drug is effective based on these results.
    2. There is a 4% difference in efficacy between the antibiotics.
    3. The sample size was too small to achieve significant results.
    4. There is a statistically significant difference in efficacy between the antibiotics.
  13. Which of the following drugs can lead to the development of pulmonary fibrosis?
    1. Amiodarone
    2. Methenamine
    3. Propranolol
    4. Metoclopramide
  14. A 72-year old woman presents to the geriatrics clinic with lower back pain. She has a history of vertebral-crush fractures secondary to osteoporosis. She took hormone replacement for five years after menopause (from age 50 to 55), but she discontinued it due to the intolerable side effects. Her only other significant medical condition is gastroesophageal reflux disease (GERD). In addition to calcium and vitamin D, which of the following is the most appropriate treatment for this patient's osteoporosis?
    1. Calcitonin
    2. Alendronate
    3. Conjugated estrogens
    4. Sodium fluoride
  15. The duration of antibiotic treatment for chronic bacterial prostatitis is:
    1. 1 Week
    2. 2 Weeks
    3. 3 Weeks
    4. 6 to 12 Weeks

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